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The health benefits of the polyphenolic compound resveratrol (RSV) are increasingly being appreciated. As in vitro and in vivo studies show anti-inflammatory properties of RSV, we hypothesized that treatment with RSV would improve cognitive functions in mice. We first confirmed that intraperitoneal (i.p.) injection of RSV in drinking water (approximately 100 mg/kg/day) for 4 weeks significantly improved cognitive functions in 5XFAD mice, a mouse model for Alzheimer’s disease. This improvement was associated with a reduction in the amyloid deposition in the brain and a reduced expression of the cell death-inducing DFF45-like effector (CIDEA) in microglia in the hippocampus. Next, we showed that treatment with RSV improved cognitive functions in normal mice without amyloid pathology. Furthermore, as suggested by in vitro studies, treatment with RSV reduced TNF-α, IL-1β, IL-6, CCL2, CXCL10, and CD68 expression in the brain. Finally, we also showed that RSV treatment inhibited neuronal degeneration in the CA3 subfield of the hippocampus after transient forebrain ischemia. Taken together, our data showed that RSV improved cognitive functions in mice.Pseudomonas aeruginosa is an important opportunistic pathogen that causes a wide variety of infections. This opportunistic pathogen must adapt to survive and to multiply within the host. The expression of virulence factors is controlled by the transcriptional regulator PqsR. PqsR controls the expression of a large number of genes involved in the synthesis of the anti-inflammatory pyocyanin pigment, the synthesis of the siderophores pyoverdine and pyochelin, the cytochrome c oxidase (a terminal electron acceptor), and the biosynthesis of alkylquinolone signal molecules. The expression of virulence genes is not regulated in the presence of these signals, and they can function as auto-inducers. How these signals are processed to regulate PqsR is not understood. Our model system for studying the regulation of virulence gene expression in P. aeruginosa has been: (i) purifying the Pqs

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