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Release Date. The PC version was released on April 30, 2008 in the United States and reached the international.Using black widow spider venom as a tool to study the cathepsins and lysosomal proteolytic pathways in the nervous system.
The present study describes the lysosomal proteolytic pathways in the nervous system of the black widow spider using the venom of female Nephila clavata as a model. The results show that the polypeptides present in the venom are mainly comprised of cysteine proteases, metalloproteases and glycosidases. The lysosomal proteases present in the crude venom are similar to those of other arachnid venoms (Arachnoserpentes). The presence of acid phosphatases, serine proteases and arylesterases suggests the participation of additional lysosomal hydrolytic enzymes in the venom. Proteins of 60, 65 and 110 kDa have been purified by affinity chromatography. These proteins were separated in a preparative scale by reverse phase HPLC. One of the purified proteins is a cysteine protease similar to cysteine proteases found in vertebrate lysosomes and, therefore, it is named CLAVATA Cysteine Protease-1 (CCP-1). Another purified protein is a cysteine protease identical with Cathepsin L, which has been reported to be an important lysosomal cysteine protease in rat brain. This is the first description of active proteolytic enzymes in the venom of a black widow spider. The active proteases in the venom showed very low proteolytic activity on casein and collagen, and probably the venom has not functions as a potent toxin in the prey. The venom also shows strong hemolytic activity; however, crude venom does not kill mice. Therefore, the venom and the purified proteins might be useful tools to study the lysosomal proteolytic pathways in the nervous system.Q:

I do not know how to use the SearchView in Android

I want to use SearchView.OnQueryTextListener to get the content editText.
But the method String suggestion has some error.
In the method queryText you can not find the method getContext().
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